The invention establishes a comprehensive performance evaluation method capable of being applied to rotor-stator mixers of a wide variety of shapes and modes of circulation. The method evaluates mixer performance by determining a homogenization index: H.I. for the rotor-stator mixer and evaluating the magnitude of a shape-dependent term for the overall mixer. The shape-dependent term is included in the H.I., is obtained by measuring rotor and stator dimensions and the motive power and flow during operation, and is a numerical value that is unique to each mixer.