LEIBNIZ INSTITUTE FOR NATURAL PRODUCT RESEARCH AND INFECTION BIOLOGY E.V. HANS-KNOELL-INSTITUT (HKI)
发明人:
MAKAROV, VADIM A.,COLE, STEWART T.,MOELLMANN, UTE
申请号：
CA2652841
公开号：
CA2652841C
申请日:
2006.05.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Novel benzothiazin derivatives of formula (I) and their use as antibacterial agents in infectious diseases caused by bacteria, especially tuberculosis (TB) and leprosy caused by mycobacteria, wherein R1 and R2are, independently each from other, NO2, CN, CONR7R8, COOR9, CHO, halogen, NR7R8, SO2NR7R8, SR9, OCF3, mono-, di or trifluoromethyl； R3 and R4 are, independently each from other, H, a saturated or unsaturated, linear or branched aliphatic radical having 1-7 chain members, cycloalkyl having 3-6 carbon atoms, benzyl, SR9, OR9； R5 and R6 are, independently each from other, a saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-8 chain members, cycloalkyl having 3-6 carbon atoms, phenyl, or R5 and R6 together represent a bivalent radical -(CR9 2)m-, or R5 and R6 together represent bivalent radicals: formula (II) or (III), wherein m is 1-4, or represent bivalent radicals a saturated or unsaturated mono or polyheterocycles with heteroatoms N, S, O and substituted by (R10)x, wherein x is 1-4.
