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PROCEDE DE RESOLUTION DE 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTIAZOL ET COMPOSES INTERMEDIAIRES
专利权人:
Crystal Pharma S.A.U
发明人:
申请号:
EP06755330.5
公开号:
EP1884514B1
申请日:
2006.05.09
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Method for resolving racemic 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (I) or for enriching a mixture with an excess of one enantiomer. Method for resolving racemic 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (I) or for enriching a mixture with an excess of one enantiomer comprises; (a) reacting the racemate (or enriched mixture) with a chiral acid of formula (IV) as an organic solution, optionally mixed with water; and (b) (fractional) crystallization of a mono-salt, diastereomerically pure or enriched, of formula (V). R : phenyl or alkylphenyl; and X : anion of (IV). An independent claim is included for diastereoisomeric salts, optically pure or enriched, of formula (V). [Image] ACTIVITY : Antiparkinsonian; Neuroleptic; Hypotensive. No details of tests for these activities are given. MECHANISM OF ACTION : Dopamine D2 agonist.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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