The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity..本發明係關於一種具化學式(I)的化合物,或其幾何異構物、鏡像異構物、非鏡像異構物、外消旋體、阻轉異構物、醫藥上可接受鹽類、前藥或溶劑化物。本發明進一步關於一種包含具化學式(I)的化合物之組合物。本文所述之化合物及組合物可用於抑制NADPH氧化酶的活性。