W. Mark Saltzman,Junwei Zhang,Jiangbing Zhou,Zhaozhong Jiang
申请号：
US14547051
公开号：
US09895451B2
申请日:
2014.11.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Polyamine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.
