DASSEUX, Jean-Louis, Henri,ONICIU, Daniela, Carmen
申请号：
MX2012007568
公开号：
MX349134B
申请日:
2003.12.23
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimers Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinsons disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.La presente invención se refiere al uso de un compuesto de fórmula I o una sal aceptable farmacéuticamente del mismo, para preparar un medicamento para tratar dislipidemia en un paciente en donde a) cada que se presente m, es independientemente un número entero que va del 0 al 5 b) cada que se presente n, es independientemente un número entero que va del 3 al 7 c) X es (CH2)z en donde z es un entero del 0 to 4 d) cada que se presenta R1, R2 R11 y R12, es independientemente H, (C1-C6) alquilo o fenilo, en donde R1, R2, R11 y R12 no son simultáneamente H ( e) cada que se presenta Y1 e Y2, es independientemente COOH, COOR3.
