Sophie Helene Nutten,Nanda De Groot,Valerie Francoise Verhasselt
申请号：
US15580180
公开号：
US10478472B2
申请日:
2016.06.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention relates to the administration of a combination of TGF-β and one or more peptides comprising specific sequences of β-lacto-globulin. The peptides are hypoallergenic but retain the capability to induce tolerance to the native protein. The combination of TGF-β and one or more of these peptides has the therapeutic effect of inducing and maintaining oral tolerance towards newly introduced proteins, in particular, at the weaning period. The combination can modulate the infant and toddler immune response to allergens.
