MADERA, DMITRIJ ALEKSANDROVICH,曼德拉 迪密崔,KARABELSKII, ALEKSANDR VLADIMIROVICH,卡拉班斯基 亚莉珊卓,卡拉班斯基 亞莉珊卓,IVANOV, ROMAN ALEKSEEVICH,伊凡诺 罗马,伊凡諾 羅馬,MOROZOV, DMITRY VALENTINOVICH,摩罗佐 狄密崔,摩羅佐 狄密崔,SEVERINO
申请号：
TW108133034
公开号：
TW202016130A
申请日:
2019.09.12
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.本發明涉及生物技術、分子生物學和醫學領域，特別是涉及核酸酶及其應用。更具體地說，本發明涉及PaCas9核酸酶。本發明還涉及編碼所述核酸酶的核酸；包含所述核酸的基因構建體、表達載體、遞送載體；包含所述核酸酶或編碼所述核酸酶的核酸的脂質體；用於產生核酸酶的方法；遞送方法；以及包含編碼所述核酸酶的核酸的宿主細胞。
