Gloria González Aseguinolaza;Jesús María Prieto Valtueña;Lucía María Vanrell Majó
发明人:
Gloria González Aseguinolaza,Jesús María Prieto Valtueña,Lucía María Vanrell Majó
申请号：
US13508494
公开号：
US20120225933A1
申请日:
2010.11.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The application relates to gene constructs for inducible hepato-specific expression of polynucleotides of interest in response to an inducer agent, said constructs comprising (i) an inducible bi-directional operator-promoter with at least one responsive element to said inducer agent flanked by two hepato-specific promoters acting in divergent manner, (ii) a first nucleotide sequence encoding a transactivator which may be activated by said inducer agent operatively coupled to the first hepato-specific promoter and (iii) a second nucleotide sequence operatively coupled to the second hepato-specific promoter, wherein the promoters are induced as a consequence of the binding of the transactivator to the operator region of the operator-promoter in the presence of the inducer agent.
