Disclosed in the present disclosure are a composition for skin whitening containing ginseng-derived exosome-like vesicles and a method for preparing the ginseng-derived exosome-like vesicle. The ginseng-derived exosome-like vesicle may have a diameter of 20-500 nm and may be isolated from ginseng root. The composition containing the ginseng-derived exosome-like vesicles as an active ingredient has an effect of preventing, improving or treating a skin pigmentation disease such as melasma, freckle, lentigo, nevus, melanoma, etc. by effectively suppressing melanin production.本發明內容揭露了一用於皮膚美白且含有人參衍生（ginseng-derived）類外泌體囊泡（exosome-like vesicles）的組合物及用於製備此人參衍生類外泌體囊泡的方法。 由人參衍生而來的類外泌體囊泡可具有20-500奈米的直徑，且可從人參根中分離而來。此含有人參衍生類外泌體囊泡作為活性成分的組合物，透過有效抑制黑色素生成，具有預防、改善或治療皮膚色素沉著病如肝斑（melasma）、斑點（freckle）、雀斑（lentigo）、痣（nevus）、黑色素細胞瘤（melanoma）等的效果。
