The present invention relates to compositions, methods and kits for the treatment of pain. In particular, the compositions, methods and kits are for the treatment of pain associated with headache or migraine or period pain. In particular, the invention includes a pharmaceutical combination for treating pain comprising a first pharmaceutical composition comprising paracetamol and / or a NSAID and a pharmaceutically acceptable diluent, excipient or carrier and a second pharmaceutical composition comprising paracetamol and/or a NSAID, a sedating antihistamine and a pharmaceutically acceptable diluent, excipient or carrier. Preferably, the NSAID is ibuprofen.
