#$%^&*AU2020101614A420200910.pdf#####ABSTRACT The invention relates to the technical field of tilapia cultivation, and discloses a tilapia cultivation method for preventing and controlling streptococcus disease, which comprises overwintering fish species cultivation, first cultivation and second cultivation. In this invention, the farming mode of two cultivation a year is adopted to effectively prevent the simultaneous meeting of "three-high" conditions at the same time, thus achieving the effective prevention and control of streptococcosis in tilapia. At the same time, the use amount of the medicine for preventing and controlling streptococcosis is indirectly reduced, by which the environmental pollution caused is reduced. It promotes the sustainable development of tilapia breeding, and increases the output of tilapia. It also improves the profit of the farmers, and improves the quality and commercial value of the tilapia.