ДАМИКО Лиза А. (US),ФЕРРАРА Наполеоне (US),ЛОУМЭН Генри Б. (US),МЭН Юй-Цзюй Г. (US),ЙЕУНГ Йнк Энди (US)
申请号：
RU2011119447/10
公开号：
RU2011119447A
申请日:
2009.10.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. Variant IgG, comprising the Fc region of human IgG containing two or more amino acid substitutions, compared with the Fc region of human IgG wild-type, in two or more amino acid residues 251, 252, 307, 308, 378, 428, 430, 434 and 436 according to the Kabat EU numbering system, where the variant IgG has an increased half-life compared to the half-life of an IgG having a wild-type human IgG Fc region, and where at least two amino acid substitutions are at amino acid residues 251, 252, 307, 308, 378, 428, 430, 434 or 436, and amino acid substitution in amino acid m residue 251 represents a substitution for aspartic acid or glutamic acid, the amino acid substitution at amino acid residue 252 represents a substitution for tyrosine, amino acid substitution at amino acid residue 307 represents a substitution for glutamine, amino acid substitution at amino acid residue 308 represents a substitution for proline, amino acid substitution for amino acid residue 378 represents a substitution for valine, an amino acid substitution at amino acid residue 428 represents a substitution for valine, amino acid substitution at amino acid residue 43 0 represents a substitution for alanine or lysine, the amino acid substitution at amino acid residue 434 represents a substitution for alanine, serine or tyrosine, and the amino acid substitution at amino acid residue 436 represents a substitution for isoleucine. 2. Variant IgG according to claim 1, comprising an amino acid substitution in amino acid 308 for proline and an amino acid substitution in amino acid 434 for alanine. Variant IgG, including the Fc region of human IgG containing three or more amino acid substitutions, compared with the Fc region of human IgG wild-type, in three or more amino acids1. Вариантный IgG, включающий Fc-участок человеческого IgG, содержащий две или более аминокислотных замен, по сравнению с Fc-участком человеческого IgG дикого типа, в двух или более аминокислотных остатках 251, 252, 307, 308, 378, 428, 430
