Use of phosphorylated tau and p38gamma to treat a neurological condition

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专利权人:

Macquarie University

发明人:

Ittner, Lars Matthias,Ittner, Arne Anselm

申请号：

AU2017225907

公开号：

AU2017225907A1

申请日:

2017.03.01

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject； or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/