A system for bio-signal control of an electronic device comprising a bio-signal sensing device for detecting a bio-signal in one of a region of a shoulder, a back or a neck operative to detect a bio-signal of a nervous system a plurality of interfaces operative to communicate with said bio-signal sensing device and said electronic device a command unit of an electronic interface device operative to generate a command for operation of said electronic device and a virtual keyboard controller of said electronic device operative to implement said command without physically typing keys on a virtual keyboard is provided. An associated method is also provided.