IRM LLC;NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.
发明人:
申请号：
IL24040615
公开号：
IL240406A
申请日:
2015.08.06
申请国别(地区):
IL
年份:
2020
代理人:
摘要：
The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
