The blood vessel contraction preventive remedy medicine and the preventive remedy composition which the chemical compound which is shown with general formula (i) or designate the acid attaching salting or the hydrate as the active ingredient, accompany bypass technique are offered. < Conversion 1 > The blood vessel contraction preventive remedy medicine and the preventive remedy composition which accompany the bypass technique of this invention are effective to the prevention or remedy of the blood vessel contraction which accompanies bypass technique.一般式(I)で示される化合物またはその酸付加塩もしくは水和物を有効成分とする、バイパス術に伴う血管攣縮予防治療剤および予防治療組成物を提供する。【化1】本発明のバイパス術に伴う血管攣縮予防治療剤および予防治療組成物は、バイパス術に伴う血管攣縮の予防もしくは治療に有効である。