Oregon Health & Science University;Sanofi Pasteur, Inc.
发明人:
申请号：
EP15871236.4
公开号：
EP3233116A4
申请日:
2015.12.18
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
