Non Human Animal Models for Increased Retinal Vascular Permeability

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专利权人:

发明人:

Abdoulaye Sene,Ramin Tadayoni,Jose Sahel,Alvaro Rendon

申请号：

US14174963

公开号：

US20140186960A1

申请日:

2014.02.07

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention relates to a non human animal model for increased retinal vascular permeability wherein said increased retinal vascular permeability is induced by inhibiting in Müller cells of said animal the expression of a gene encoding for Dp71 or a dystrophin associated protein (DAP). Furthermore, the present invention relates to methods and compositions for the treatment of a disease associated with an increased retinal vascular permeability in a subject in need thereof.

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