Yu Qian,Li Juan Zhang,Zhi Min Wu,Li Ying Zhou,Wei Jiang,Li Ling,Qian Luo,Xin Dong Guo
申请号：
US13561105
公开号：
US09101547B2
申请日:
2012.07.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.
