#$%^&*AU2016210778A120160825.pdf#####ABSTRACT The present invention provides a novel diazepine compound that blocks the I 7 ncurrent or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention 5 relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R, R2 , R3 , and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl； R ；and R may be linked to form lower alkylene； A' is lower alkylene optionally substituted with one or 10 more substituents selected from the group consisting of hydroxyl and oxo； Y and Y2 are each independently -N= or -CH=； and R is group represented by (2) wherein R6 and R are each independently hydrogen or organic group； R6 and R7 may be linked to form a ring together with the neighboring group -XA-N-XE-； XA and XS are each 15 independently a bond, lower alkylene, etc. r Yl N 4fk R 1 t 0 R R4 R-XR N-~ (2) ?h /
