National Institute of Biological Sciences; Beijing
发明人:
Zhiyuan Zhang,Xiaodong Wang,Xiaoguang Lei,Yaning Su,Sudan He,Hanying Ruan,Liming Sun
申请号：
US15632412
公开号：
US20170290790A1
申请日:
2017.06.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
