The invention relates to a kit for delivering a compound of interest in situ to a patient in need thereof, comprising a chamber (2) comprising a closed shell made of the semi-permeable membrane, the pouch comprising at least one connector (3) comprising a body attached to the sheet, and a catheter (4) that can be connected to said connector at one end and that can be connected to a source of delivery of a compound of interest at the other end, as well as methods of use of such kit.