The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. For example, the core construct may be conjugated with a functional element via the click chemistry.本揭示內容提出了多種中心核構建體。根據本揭示內容的多種實施方式,這些中心核構建體可用以組設多種藥物分子。舉例來說,所述中心核構建體可透過鏈接化學而與功能性元件複合。