JACOB SWIDORSKI,NICHOLAS A. MEANWELL,ALICIA REGUEIRO-REN,SING SIT,JIE YUEN - CHEN,YAN CHEN
申请号：
ARP130100466
公开号：
AR089996A1
申请日:
2013.02.14
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. Characteristic 1: a compound, including the acceptable salts of the drug, whose characteristic is from a group including: a formula compound (1)；a. A formula compound (2)；a. A formula compound (3)；And a compound formula (4),R1 is isopropyl or isopropyl； J and E are independent h-o-ch832323；and E is absent when the double bond is present； X is selected from the group of the cycloalkyl ring C₄₋₈,cycloalkenyl C₄₋₈,C₄₋₉ spirocycloalkyl,C₄₋₉ spirocycloalkenyl,oxacicloalquilo C₄₋₈,dioxacycloalkyl C₄₋₈,1.Oxacicloalquenilo C832626dioxacicloalquenilo C₆₋₈,C832626 cyclomycinoxacyclodialquenilo C₆,C₆₋₉ oxaspyrocycloalkyl and C₆₋₉ oxaspirocycloalkenyl,wherein X is substituted with A, where A is at least one member selected from the group of -H, -halo, -hydroxy, -C₁₋₆ alkyl,-C₁₋₆ alkoxy,-C₁₋₆-Q alkyl, C₁₋₆-Q alkyl substituted with -alkyl, -CN, -CF₂Q, -NR⁸R⁹,-Coordination and - coordination；X can also be selected from the formula group (5)；Q selected from arilo group, alien, alien, alternative,- yes.-Nr2,SO₂R⁷,-CONHSO R y -CONHSO NR RR2 es-h, lease No. c1832131；C₁₋₆ alkyl substituted with -alkyl or C₁₋₆ alkyl substituted with -aryl； And it is selected from the group of -COOR²,-C (O) NR SO R-C (O) NHSO NR R-No. 832222；-I'm 832222-C₃₋₆-COOR² cycloalkyl,-Alquenil c83228331-832626-coordination；-Cquin-COOR² alkynyl,-alkyl C₁₋₆-COOR²,C₁₋₆ alkyl substituted with -alkyl, -COOR²,CF₂-COOR²,-NHC (O) (CH) -COOR-SO NR C (O) Rtetrazole and -CONHOH, where n = 1-6； W is absent, or is CH₂ or CO； R³ is -C₁₋₆ alkyl or C₁₋₆ alkyl substituted with -alkyl； R⁴ is selected from the group of -H, -C₁₋₆ alkyl,-alquil C -C (OR) -cicloalquilo C-Replaced c83218c833331-832626 asphalt-c833183268c83268c833268c8326；-C833218c-83316262-q1 asphalt,-C₁₋₆ alkyl-C₃₋₆-Qal cycloalkyl,Arilo, heterosexual, heterosexual substitution,-Cocoa 8310,-SO₂R⁷,-I'm 832222Or other members of the formula group (6),e. If W is a company, r830810 or r8309 cannot be cor8310 or cocor8310a； in the case of W is a company, Q1 is selected f
