GAETANO BRAMBILLA,DAVID ANDREW LEWIS,BRIAN JOHN MEAKIN,TANYA CHURCH
申请号：
BRPI0811786
公开号：
BRPI0811786A2
申请日:
2008.06.27
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
A metered dose inhaler actuator for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas. The actuator (2) comprises: - a nozzle block (5) having a bore (11) to receive a valve stem (7), - a sump (8) in connection with a bore (11), wherein the propellant formulation expands upon actuation of the inhaler, - a nozzle channel (6), exiting from the sump (8) and aligned with a mouthpiece (4) wherein the sump (8) is characterised by an internal volume comprised between 12 and 2 mm 3 to avoid deposits of the medicament during the delivery into the chamber and/or into the nozzle channel which could cause a reduction in the delivered dose and an increase in the occurrence of the clogging of the inhaler. The actuator of the invention is particularly useful in the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient/s of the formulation is/are particularly high and in particular suitable to administer at least 100 ¼g/dose, preferably at least 200 ¼g/dose, even more preferably at least 400 ¼g/dose.
