Vivekkumar B. Patel,Hongran Wang,Vivek P. Singh,Erin Lynn Reineke,Megumi Mathison,Austin J. Cooney,Todd Rosengart
申请号：
US15552253
公开号：
US20180066252A1
申请日:
2016.02.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.
