PROCESS FOR THE PREPARATION OF AMORPHOUS FORM OF SOFOSBUVIR

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专利权人:

发明人:

SINGH GIRIJ PAL,SRIVASTAVA DHANANJAI,MEHARE KISHOR GULABRAO,SHIVDAVKAR RADHAKRISHNA BHIKAJI,MALIK VINEET,VINCHURKAR ARJUN NISHIKANT,DEOKAR SHARAD CHANDRABHAN,DANGE ABHIJEET AVINASH

申请号：

IN1856/MUM/2015

公开号：

IN2015MU01856A

申请日:

2015.05.11

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention provides process for preparation of amorphous sofosbuvir by using spray drying, agitated thin film dyring (ATFD), and freeze drying (lyophilization) techniques. The present invention also provides process for preparation of stable Sofosbuvir premix having enhanced flow property, stability, dissolution properties that can be easily formulated into pharmaceutical compositions. Sofosbuvir premix is prepared by using various premixing agents such as kaolin, bentonite, hectorite, colloidal magnesium-aluminum silicate, silicon dioxide etc.

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中国工程科技知识中心

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