Tristan John Vaughan,Alison Jane Wilton,Stephen Smith,Sarah Helen Main
申请号：
US14223561
公开号：
US09284589B2
申请日:
2014.03.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralizing eotaxin, including methods of treatment of the human or animal body by therapy.
