Sandhu, Harpreet K.,Shah, Navnit Hargovindas,Lomuscio, Steve,Ma, Hua,Matchett, Michael Allen,Zhang, Yu-E
申请号：
NZ70827214
公开号：
NZ708272A
申请日:
2014.01.20
申请国别(地区):
NZ
年份:
2020
代理人:
摘要：
The invention relates to solid dispersions of poorly water soluble compounds, in particular 4-{ [(2R,3S,4R,5S)-4-(4-chloro-2-fluorophenyl)-3-(3-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-pyrrolidine-2-carbonyl]amino} -3-methoxy-benzoic acid, formed by solvent co-precipitation or spray drying with a stabilising polymer, resulting in improved bioavailability, safety and tolerability of said compounds, and where in the stabilising polymer is poly(methacrylic acid)-co-methyl methacrylate (EUDRAGITR L-100), poly(methacrylic acid)-co-methyl methacrylate (Eudragit L100-55) or poly(vinylpyrrolidone-co-vinyl acetate) (6+4).
