HARRIS, LUKE B.,TAVARES, DANIEL,RUI, LINGYUN,FISHKIN, NATHAN ELLIOTT,SHIZUKA, MANAMI,MILLER, MICHAEL LOUIS,CHARI, RAVI V.J.
申请号：
CA2957964
公开号：
CA2957964A1
申请日:
2015.09.02
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
