GAY DE SAINT MICHEL, MYRIAM,LAFONT, SYLVAINE,BAILLON, BRUNO,GORTER DE VRIES, ROELOF JOHANNES,LONG, ALAN,MENG, CHARLES Q.,LE HIR DE FALLOIS, LOIC PATRICK,YANG, CHUNHUA,KOZLOVIC, STEPHANE
申请号：
ARP170100879
公开号：
AR108184A1
申请日:
2017.04.05
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
1. The preparation of isoxazolina antiparasitic compound concentrated from midget by quinine based phase transfer catalyst. There is also a quinine based phase transfer catalyst and a solution form containing toluene, an isoxazolina compound. 1. Characteristic 1: a preparation process of isoxazolina compound (1),He was rich in a dwarf, where: B1,B.,B3,Each R is an independent C-R or N, each R is an independent h, halogen, cyanogen,alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylamino, dialkylamino or alkoxycarbonyl； R¹ is C₁₋₃alkyl or C₁₋₃haloalkyl； Y is an optionally substituted phenylene, naphthylene, indanylene, a 5- or 6-membered heteroarylene or an 8-10 membered fused heterocyclylene, where optional substituents are selected from the group consisting of halogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl , alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylamino, dialkylamino,-Cn-no-832222 and nh-8322-c (= s) -；Q is T-NR-3.This group (- ch8322 -) (- ch832222 -) n-r3,Oh, nh832222,alcoxi haloalcoxi alquilamino haloalquilamino dialquilamino halodialquilamino tiol alquiltio haloalquiltio alquilsulfinilo haloalquilsulfinilo alquilsulfonilo haloalquilsulfonilo o un anillo carbociclilo heterociclilo o heteroarilo de 5 6 miembros opcionalmente sustituido T es (CH)CH (CH)Page: 1C (= O) or C (= s)；R² is H, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, alkylcarbonyl or alkoxycarbonyl； R³ is H, OR⁷,No. 8312； r8313 o Q1；Or pitch, haloalkyl, alquenilo, haloalquenilo, pitch, haloalkyl, cyclopentyl, pitch, cyclopentadienyl, tar, carbonate, aminobenzene, butadiene carbide or dialectical carbide, a. One or more substitutes independently selected from r830808 can be selected to replace each of them；O r 2 and R 3, together with the attached nitrogen, shall form a ring containing 2 to 6 carbon atoms,
