ENSCORE, DAVID JAMES,TAGLIAFERRI, FRANK,DAMON, STEVEN PAUL,SMITH, ALAN,GAULDING, JEFFREY C.
申请号：
CA2937649
公开号：
CA2937649A1
申请日:
2015.01.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can exhibit biphasic or sustained kinetics of release with an immediate portion released rapidly and an extended portion released in a prolonged manner when exposed to a dissolution medium. The prolonged aversive agent release provides deterrence against extraction of drug from fresh and used patches and serves to prevent accidental misuse of used patches by children. The abuse deterrent and misuse deterrent patch systems can be used for transdermal delivery of therapeutically active agents and particularly those drugs that are highly prone to abuse such as opiate and opioid analgesics and stimulants.
