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Stable anti-tnfr1 polypeptides, antibody variable domains & antagonists
专利权人:
GLAXO GROUP LIMITED
发明人:
DE SILVA INUSHA,SEPP ARMIN,STOOP ADRIAAN ALLART
申请号:
NZ59911410
公开号:
NZ599114A
申请日:
2010.10.25
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is an anti-TNFalpha receptor type 1 immunoglobulin single variable domain comprising the amino acid sequence that is at least 95% identical to the sequence of DOM1h-574-208 (SEQ ID NO: 59), wherein the sequence is as defined in the complete specification. Also disclosed is the use of the anti-TNFalpha receptor type 1 immunoglobulin single variable domain in the manufacture of a medicament for treating and/or prophylaxis of an inflammatory condition.
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