Disclosed is an anti-TNFalpha receptor type 1 immunoglobulin single variable domain comprising the amino acid sequence that is at least 95% identical to the sequence of DOM1h-574-208 (SEQ ID NO: 59), wherein the sequence is as defined in the complete specification. Also disclosed is the use of the anti-TNFalpha receptor type 1 immunoglobulin single variable domain in the manufacture of a medicament for treating and/or prophylaxis of an inflammatory condition.