PILLAY VINESS,CHOONARA YAHYA ESSOP,SHAIKH RUBINA PERVEEN,DU TOIT LISA CLAIRE
申请号：
ZA201304709
公开号：
ZA201304709B
申请日:
2013.06.24
申请国别(地区):
ZA
年份:
2015
代理人:
摘要：
A pH responsive and mucoadhesive pharmaceutical dosage form for the release of a pharmaceutically active agent is described. The dosage form includes a mucoadhesive layer for site-specific mucoadhesion, a water-insoluble outer layer, and an intermediate layer including one or more pharmaceutically active agents for site-specific delivery. The different membranous layers perform different functions in order to create a drug delivery system which is able to deliver a drug to a specific site, for a particular period of time and with a specific drug release pattern. The dosage form can have two or more intermediate layers, each layer comprising an active agent. The mucoadhesive layer can also include an active agents. The dosage form is preferably an oral or buccal delivery form for release of the active agent into the gastro intestinal tract. The intermediate layer can be an electrospun fibrous membrane layer containing the active agent.
