MOLÉCULES DE LIAISON D'ANTIGÈNE COMPRENANT UN TRIMÈRE DE LIGAND DE LA FAMILLE TNF ET UN FRAGMENT DE LIAISON PD1

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专利权人:

F. Hoffmann-La Roche AG

发明人:

申请号：

EP16169487.2

公开号：

EP3243832A1

申请日:

2016.05.13

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to PD1 and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/