NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY;ＯＲＴＨＯＲＥＢＩＲＴＨ株式会社;国立大学法人名古屋工業大学;ORTHOREBIRTH CO.LTD.
发明人:
KASUGA Toshihiro,春日敏宏,NISHIKAWA Yasutoshi,西川靖俊
申请号：
JPJP2017/016931
公开号：
WO2017/188435A1
申请日:
2017.04.28
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
There is a demand for a novel method for manufacturing, with commercial efficiency, a bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber comprising PLGA by using electrospinning, and a novel bone-regeneration material manufactured using the method. According to the present invention, a PLGA resin is heated in a kneader so as to be softened until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is poured while the blade of the kneader is being rotated, and mixed with the softened PLGA resin. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by the solvent through agitation for a prescribed period of time to prepare a spinning solution in which the calcium phosphate fine particles are dispersed without being aggregated in a solution having the PLGA resin dissolved therein. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.Il existe une demande d'un nouveau procédé de fabrication, avec une efficacité commerciale, d'un matériau de régénération osseuse qui contient des particules de phosphate de calcium dans une fibre biodégradable comprenant du PLGA par électrofilage, et un nouveau matériau de régénération osseuse fabriqué au moyen du procédé. Selon la présente invention, une résine de PLGA est chauffée dans un malaxeur de façon à être ramollie jusqu'à ce que la viscosité de la résine devienne de 102 à 107 Pa.s. Une poudre de particules fines de phosphate de calcium est versée tandis que la p
