LUO, PETER PEIZHI,DU, FANGYONG,LIU, GUIZHONG,LI, YAN
申请号：
CA3095076
公开号：
CA3095076A1
申请日:
2019.03.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure provides antibodies that bind to the T-cell co-inhibitor ligand programmed death-ligandl (PD-L1) protein, and methods of use. In various embodiments of the disclosure, the antibodies are fully human antibodies that bind to PD-L1. In certain embodiments, the present disclosure provides multi-specific antigen-binding molecules comprising a first binding specificity that binds to PD-L1 and a second binding specificity that binds to a tumor cell antigen, an infected cell-specific antigen, or a T-cell co-inhibitor. In some embodiments, the antibodies of the disclosure are useful for inhibiting or neutralizing PD-L1 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection.
