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HETEROCYCLIC COMPOUNDS AND USE THEREOF
专利权人:
NESHNL KHELS RESERCH INSTITYUTS
发明人:
CHAO Yuj-Shen (US),ЧАО Юй-Шэн (US),SYA Kak-Shan (TW),СЯ Как-Шань (TW),ZHEN Tszin-Chzhi (TW),ЖЭНЬ Цзинь-Чжи (TW),TSOU Lun Kelvin (TW),ЦОУ Лунь Келвин (TW),CHZHEN Tszyun-Tun (TW),ЧЖЕНЬ Цзюн-Тун (TW)
申请号:
RU2017109355
公开号:
RU0002704008C2
申请日:
2015.09.21
申请国别(地区):
RU
年份:
2019
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a novel heterocyclic compound of formula (I). In formula (I), each of R1 and R2 independently represents H, a halogen atom, an amino, C1-6 alkyl, C4-5 heterocycloalkyl containing in ring 1–2 nitrogen atoms or nitrogen atom and oxygen atom; or R1 and R2 together with two carbon atoms to which they are bonded, are C4 heterocycloalkyl containing a nitrogen atom as a heteroatom, phenyl or 5-member heteroaryl containing a nitrogen atom in the cycle, a sulphur atom or two nitrogen atoms, where each of the C4-5 heterocycloalkyl, phenyl and heteroaryl is optionally substituted with a halogen atom, C1-6 alkyl, C1-6 alkoxy or C(O)ORa, in which Ra is H or C1-10 alkyl; and each of R3 and R4 independently represents NRbRc, or , wherein at least one of R3 and R4 is , in which each of Rb and Rc independently represents H or C1-6 alkyl; R5 is H, C1-6 alkyl, benzyl, optionally substituted cyano, or 5-member heteroaryl C1 alkyl containing 2 nitrogen atoms as heteroatoms; R6 is H; L1 is 5-member heteroaryl containing 3 nitrogen atoms as heteroatoms, C4-5 heterocycloalkyl containing 1–2 nitrogen atoms in a cycle, NH or NRd, in which Rd is C(O)(CH2)2CHNH2CO2Re, where Re is H or C1-6 alkyl; R7 is H, C1-6 alkyl, C1-6 alkoxy, C3-10 cycloalkyl, C4 heterocycloalkyl containing in the cycle a nitrogen atom or a nitrogen atom and an oxygen atom, phenyl or 5- or 6-member heteroaryl containing 1–3 nitrogen atoms as heteroatoms, wherein each of said C1-6 alkyl, C1-6 alkoxy, C3-10 cycloalkyl, C4 heterocycloalkyl, phenyl and heteroaryl is optionally substituted with hydroxy, hydroxy C1-6 alkyl, halogen atom, amino C1-6 alkyl, amino C3-10 cycloalkyl, amino C4 heterocycloalkyl, C3-10 cycloalkyl, C4 heterocycloalkyl containing a nitrogen atom and an oxygen atom in the cycle, phenyl, optionally substituted with halogen, or 5-member heteroaryl containing 2 nitrogen atoms as heteroatoms; m is 1–6; n is equal to 2–3; each of R8 and R9 independently represen
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