Ragupathy Madiyalakan,Christopher F. Nicodemus,Michael A Hollingsworth
申请号：
US15541451
公开号：
US20180002441A1
申请日:
2016.01.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods for increasing the permeability of a stroma around a neoplasm, and particularly to cancer cells associated with solid tumors. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention increases the delivery of the anticancer agent to the site of, for example, a solid tumor in a subject. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention potentiates a tumor's responsiveness and sensitivity to the anti-cancer agent.
