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Thiazole Derivatives as Alpha 7 NACHR Modulators
专利权人:
LUPIN LIMITED
发明人:
Neelima Sinha,Navnath Popat Karche,Anil Kashiram Hajare,Baban Rupaji Thube,Firoj Aftab Raje,Dnyaneshwar Changdeo Bhanage,Sudhakar Maruti Balgude,Venkata P. Palle,Rajender Kumar Kamboj
申请号:
US14439120
公开号:
US20150299178A1
申请日:
2013.11.11
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5 and m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly α7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
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中国工程科技知识中心
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