The present invention is to provide a medical tissue-marker which enables theidentification of a location even from the outside of an organ, can remaintopical over a longperiod, and enables the easy identification of a marked location within thewhole organ also to provide a manufacturing method for the medical tissue-marker. The medicaltissue-markeras in the present invention includes a vesicle formed by the synthesis of aphospholipid and a near infrared fluorescent dye, and an emulsion formed bythe synthesisof the phospholipid and an X-ray contrast medium, and has agglomeratedclusters whereinthe vesicle and the emulsion are contained in a hydrophilic solvent and aplurality ofcapsules are formed by means of an emulsifier.
