Human Single-Chain T Cell Receptors

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专利权人:

David M. Kranz

发明人:

David M. Kranz,David H. Aggen

申请号：

US13500123

公开号：

US20120252742A1

申请日:

2010.10.06

申请国别(地区):

US

年份:

2012

代理人:

摘要：

A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.

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