Erica M. Phillips,Richard Hantke,Daniel Baird,Mike Rainone,Thomas Edward Plowman,Talbot Presley
申请号：
US11955779
公开号：
US20120143024A1
申请日:
2007.12.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.
