RAJAGOPALAN, Srinivasan,APPUKUTTAN, Prasad,NARASINGAPURAM ARUMUGAM, Karthikeyan,UJJINAMATADA, Ravi Kotrabasaiah,GEORGE, Shyla,LINNANEN, Tero
申请号：
ES14722686
公开号：
ES2658183T3
申请日:
2014.04.03
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound that is of formula (I) ** Formula ** in which Z1 is N and Z2 is CH, or Z1 is CH and Z2 is N, or Z1 and Z2 are N； Z is CH or N； A is a phenyl ring or a 5-12 membered heterocyclic ring； R1 is H, C1-7 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, C1-7 alkoxy, C1-7 alkylcarbonyl, amino, hydroxy, hydroxyalkyl C1-7, haloalkyl C1-7, alkylamino C1 -7 C1-7 alkyl, -R16-C (O) -R17 or -E-R6； R2 is H, halogen or C1-7 alkyl； B is a 5-12 membered carbocyclic ring and R3 is halogen, C1-7 alkyl, C1-7 alkoxy, C1-7 haloalkyl or C1-7 haloalkoxy； or B is a 5-12 membered heterocyclic ring and R3 is H, halogen, C1-7 alkyl, C1-7 alkoxy, C1-7 haloalkyl or C1-7 haloalkoxy； R4 is H, halogen, C1-7 alkyl or oxo； R5 is H, -C (O) R7, -SO2R8 or an optionally substituted 5-6 membered heterocyclic ring； R6 is an optionally substituted 5-6 membered heterocyclic ring； R 7 is C 1-7 alkyl, C 2-7 alkenyl, C 1-7 alkoxy, C 1-7 alkoxy C 1-7 alkyl, C 1-7 carboxyalkyl, C 1-7 alkoxy carbonyl C 1-7 alkyl, C 1-7 alkylamino C 1-7 alkyl, -NH-R10 or -NH-X1-R11； R8 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C1-7 hydroxyalkyl, -NR13R14, -NH-X2-R15, phenyl or an optionally substituted 5-6 membered heterocyclic ring； R10 is C1-7 alkyl or C3-7 cycloalkyl； R11 is phenyl or an optionally substituted 5-6 membered heterocyclic ring； R13 and R14 are, independently, H, C1-7 alkyl or C3-7 cycloalkyl； R15 is phenyl or an optionally substituted 5-6 membered heterocyclic ring； R16 is a bond or a C1-7 alkyl； R17 is C1-7 alkyl, C1-7 alkoxy, C1-7 alkylamino, amino or hydroxy； E is a bond or a C1-7 alkyl； X1 and X2 are, independently, a C1-7 bond or alkyl； or is a pharmaceutically acceptable salt thereof.Un compuesto que es de fórmula (I) **Fórmula** en la que Z1 es N y Z2 es CH, o Z1 es CH y Z2 es N, o Z1 y Z2 son N； Z es CH o N； A es un anillo de fenilo o un anillo heterocíclico de 5-12 miembros； R1 es H, alquilo C1-7, cicloalquilo C3-7, cicloalquil C3-7 alquilo C1-7, alcoxi C1-7, alquil C1-7 carbonilo, amino, h
