FORMULATION DE NANOPARTICULES LIPIDIQUES

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专利权人:

MODERNATX, INC.;OREGON STATE UNIVERSITY

发明人:

PATEL, SIDDHARTH,ROBINSON, EMILY,BROWN, ANNA,ALMARSSON, ORN,BENENATO, KERRY E.,SABNIS, STACI,SAHAY, GAURAV,NARAYANA, ASHWANI KUMAR

申请号：

CA3055653

公开号：

CA3055653A1

申请日:

2018.03.15

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

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