SALOME, NATHALIE,DINSART, CHRISTIANE,MICHEL, NADINE,ROMMELAERE, JEAN
申请号：
CA2802599
公开号：
CA2802599C
申请日:
2011.06.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Described are parvovirus variants derived, e.g., from H-1PV, showing higher anti-tumour potential compared to the wild type parvovirus, wherein said variant is characterized by (a) an amino acid substitution, alteration or addition, preferably substitution at position Lys96 of NS-2 and/or position Leu103 of NS-2 (together with a amino acid substituion at position Tyr595 of NS-1 in the latter case), or (b) an in-frame deletion in the parvovirus genome, preferably a deletion resulting in a large amino acid deletion in both the central part (aa 96-133) of NS-2 and the C-terminal part (aa 587-624) of NS-1. The present invention also relates to the use of said parvovirus variants for cancer therapy.
