PROCEDE DE PRODUCTION DE DERIVE DE 7H-PYROLLO[2,3-D]PYRIMIDINE ET INTERMEDIAIRE CORRESPONDANT

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专利权人:

JAPAN TOBACCO INC.

发明人:

YAMASAKI, TAKAHIRO,HARA, YOSHINORI,SAKAI, TAKAYUKI,MURAKAMI, KENGO,HARA, KATSUYOSHI,MANTA, NAOKI

申请号：

CA2991020

公开号：

CA2991020A1

申请日:

2016.07.06

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention provides: a method for producing a 7H-pyrrolo[2, 3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor； an intermediate of the 7H-pyrrolo[2, 3-d]pyrimidine derivative； and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S, 4R)-3-methyl-6-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1, 6-diazaspiro[3. 4]octan-1-yl]- 3-oxopropanenitrile, which uses a salt of an organic acid and (3S, 4R)-3-methyl-1, 6-diazaspiro[3. 4]octan-1-carboxylic acid benzyl.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/