Eric Valeur,Franck Lepifre,Didier Roche,Denis Carniato,Serge Christmann-Franck,Fabien Schmidlin
申请号：
US13061238
公开号：
US08486964B2
申请日:
2009.08.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to fused pyrrolidino-cyclopropane derivatives according to formulae (I) to (IV) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
