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Dual mechanism inhibitors for the treatment of disease
专利权人:
Aerie Pharmaceuticals; Inc.
发明人:
DELONG, Mitchell,STURDIVANT, Jill,ROYALTY, Susan
申请号:
ES10709100
公开号:
ES2553827T3
申请日:
2010.01.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound according to formula I: ** Formula ** and salts and solvates thereof, wherein R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, aryl, C1-C4 alkyl-aryl, C1-C4 alkyl-heteroaryl , C1-C4-heterocyclyl alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 carbonyl, C1-C4 carbonylamino, C1-C4 alkoxy, C1-C4 sulfonyl, C1-C4 sulfonylamino, C1-C4 thioalkyl, C1 carboxyl -C4, or form a ring with each other or with A; wherein A is C1-C4 alkyl, C1-C4 alkyl-aryl, C1-C4 alkyl-heteroaryl, or forms a ring structure with R1, R2 or R3; wherein B is hydrogen, an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, C1-C22 alkyl, C1-C22-aryl alkyl, C1-C22-heteroaryl alkyl, C2-C22 alkenyl, C2- alkynyl C22, C1-C22 carbonyl, C1-C22 carbonylamino, C1-C22 alkoxy, C1-C22 sulfonyl, C1-C22 sulfonylamino, C1-C22 thioalkyl or C1-C22 carboxyl, wherein X1, X2 and X3 are independently hydrogen , hydroxyl, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, amino, aminocarbonyl, nitro, cyano, C1-C4 carbonyl, C1-C4 carbonylamino, C1-C4 alkoxy, C1-C4 sulfonyl, C1-sulfonylamino -C4, C1-C4 thioalkyl or C1-C4 carboxyl; in which the double circle indicates an aromatic or heteroaromatic ring; and wherein each Z is independently a bond, is C1-C4 alkyl, heteroalkyl or an O atom.Compuesto segun la formula I:**Fórmula** y sales y solvatos del mismo, en la que R1, R2 y R3 son independientemente hidrogeno, alquilo C1-C4, arilo, alquil C1-C4-arilo, alquil C1-C4- heteroarilo, alquil C1-C4-heterociclilo, alquenilo C2-C4, alquinilo C2-C4, carbonilo C1-C4, carbonilamino C1-C4, alcoxilo C1-C4, sulfonilo C1-C4, sulfonilamino C1-C4, tioalquilo C1-C4, carboxilo C1-C4, o forman un anillo entre si o con A; en la que A es alquilo C1-C4, alquil C1-C4-arilo, alquil C1-C4-heteroarilo, o forma una estructura de anillo con R1, R2 o R3; en la que B es hidrogeno, un grupo arilo, un grupo heteroarilo, un grupo cicloalquilo, un grupo heterocicloalquilo, alquilo C1-C22, alquil C1-C22-arilo, alquil C1-C22-heter
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